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Expression of apoptosis-inhibiting gene,survivin in laryngeal squamous cell carcinomas

XU Xiu-yu

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Abstract

Objective To investigate the expression of survivin in laryngeal squamous cell carcinomas(LSCC).Methods Immunohistochemical technique was used to examine the expression of survivin gene in 45 cases of LSCC and 10 cases of normal laryngeal mucosa tissues.Results Survivin was expressed in 36 of 45(80%) cases of LSCC and expressed in 2 of 10 (20%) cases of normal laryngeal mucosa tissues.Expression of survivin was detected in a significantly greater proportion in LSCC than that in normal tissues.Overexpression of survivin was related to the tumor grade and lymphatic metastasis(P0.05).Conclusion Survivin may play an important role in the pathway of carcinogenesis and progression of LSCC and it may be identified as a new therapeutic target.

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What this paper is about

Objective To investigate the expression of survivin in laryngeal squamous cell carcinomas(LSCC).Methods Immunohistochemical technique was used to examine the expression of survivin gene in 45 cases of LSCC and 10 cases of normal laryngeal mucosa tissues.Results Survivin was expressed in 36 of 45(80%) cases of LSCC and expressed in 2 of 10 (20%) cases of normal laryngeal mucosa tissues.Expression of survivin was detected in a significantly greater proportion in LSCC than that in normal tissues.Overexpression of survivin was related to the tumor grade and lymphatic metastasis(P0.05).Conclusion Survivin may play an important role in the pathway of carcinogenesis and progression of LSCC and it may be identified as a new therapeutic target.

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Available abstract

Objective To investigate the expression of survivin in laryngeal squamous cell carcinomas(LSCC).Methods Immunohistochemical technique was used to examine the expression of survivin gene in 45 cases of LSCC and 10 cases of normal laryngeal mucosa tissues.Results Survivin was expressed in 36 of 45(80%) cases of LSCC and expressed in 2 of 10 (20%) cases of normal laryngeal mucosa tissues.Expression of survivin was detected in a significantly greater proportion in LSCC than that in normal tissues.Overexpression of survivin was related to the tumor grade and lymphatic metastasis(P0.05).Conclusion Survivin may play an important role in the pathway of carcinogenesis and progression of LSCC and it may be identified as a new therapeutic target.

Key concepts: Survivin, Immunohistochemistry, Carcinogenesis, Cancer research, Laryngeal Neoplasm, Apoptosis, Gene, Lymphatic system

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