Effect of Ligustrazine on the deposition of collagen in asthmatic rats

Objective To observe the effect of Ligustrazine on the collagen deposition in asthmatic rats.Methods 40 SD rats were randomly divided into 5 groups:the normal group,the model group,Dexamethasone group,the low-dose and high-dose of Ligustrazing group,8 rats in each group.The changes of collagen content in the airway wall and the thickness of reticular basement membrane,inner and outer diameter were measured by the computerized image analysis system.Results The ratio of inner diameter to outer diameter in the low-dose and high-dose of Ligustrazing group were higher than that in the model group(P0.001),and the wall contents of collagen type Ⅲ and the thickness of reticular basement membrane layer were significantly lower than that in the model group(P0.001).The effect of the ligustrazine group were similar to that of dexamethasone group,and the high-dose of ligustrazine were preferable.Conclusion Ligustrazine could inhibit the airway remodeling by the way of reducing the precipitation of collagen and the thickness of airway wall.