Effect of penehyclidine on pulmonary compliance during general anesthesia

Objective To investigate the effect of penehyclidine hydrochloride on pulmonary compliance under mechanical ventilation during general anesthesia.Methods Forty ASA class Ⅰ patients aged 24-76 years old with body mass index 18-25 kg/m2 scheduled for elective operation under general anesthesia were studied.The patients were randomly divided into experimental group and control group with 20 cases each.Midazolam 0.03 mg/kg was given iv.as premedication.Anesthesia was induced with propofol 2-2.5 mg/kg,fentanyl 3 μg/kg,vecuronium 0.1 mg/kg.Pressure controlled ventilation(PCV) was performed after tracheal intubation,PETCO2was maintained at normal range.Anesthesia was maintained with propofol and vecuronium continuous intravenous infusion.Penehyclidine hydrochloride 0.02 mg/kg was administered in experimental group and normal saline was injected in control group at 20 min after intubation.HR,MAP,SpO2,PETCO2,tidal volume (VT)and pulmonary compliance(Comp) were monitored and recorded immediately before penehyclidine(T0) and at 5(T5),10(T10),20(T20) and 30 min(T30) after penehyclidine injection.Arterial blood gases were analyzed at T0 and T30.Results Compared with those in control group,HR and MAP were not significantly changed in experimental group.VT and Comp significantly increased after medication in experimental group compared with those before.Conclusion During general anesthesia penehyclidine hydrochloride not only has less influence on hemodynamics but also could dilate bronchus and increase pulmonary compliance.