Clinical infection and drug-resistance analysis of Enterococcus

Objective To explore the current distribution and drug-resistance of the main types of clinically isolated Enterococci in the First Affiliated Hospital of Wenzhou Medical College to guide optimal clinical drug practice.Methods Retrospective analysis was performed with the source and antimicrobial susceptibility results of 635 strains of Enterococcus faecalis and Enterococcus faecium which were clinically isolated during 2008 to 2011.Results The ratios of the two types of Enterococci had a difference in different specimens.Most of Enterococci were isolated from urine specimens which accounted for the highest ratio in total,and the isolation rate of Enterococcus faecium was significantly higher than that of Enterococcus faecalis.The drug resistance rate of Enterococcus faecalis to linezolid,vancomycin,nitrofurantoin and teicoplanin were all under 5%,and to moxifloxacin and penicillin were 7.0% and 6.7% respectively,while the drug resistance rate of Enterococcus faecium to moxifloxacin,levofloxacin,ciprofloxacin,ampicillin,penicillin G and erythromycin were all above 90.0%.Enterococcus faecium were sensitive to vancomycin,teicoplanin and quetiapine.The multi-drug resistant strains of Enterococcus faecalis accounted for 26.4%,while that of Enterococcus faecium was up to 78.2%.Conclusion Enterococcus faecalis and Enterococcus faecium have different drug-resistance to 15 antimicrobial drugs.Enterococcus faecium has higher drug resistance rate and wider drug resistance spectrum.The antimicrobial drugs should be optimally chosen according to the results of susceptibility test to prevent the generation and contamination of drug resistant strains.