Relationship between Serum Alpha-fetoprotein Levels and Prognosis in Patients with Severe Hepatitis

Objective To explore the relationship between serum alpha-fetoprotein(AFP) levels and prognosis in patients with severe hepatitis.Methods According to the AFP values,280 patients with severe hepatitis were divided into three groups:group A(95 patients,AFP20 μg·L-1),group B(100 patients,AFP 20-600 μg·L-1) and group C(85 patients,AFP600 μg·L-1).The levels of AFP were detected by radioimmunoassay and chemical method shine.The curative effects were evaluated in the three groups.Results The effective rate in group B was higher than that in group A,but the difference was not statistically significant(34.0% vs 20.0%,P0.05).Compared with group C,the effective rate and serum AFP levels significantly decreased in group A and B[the effective rate:20.0% and 34.0% vs 77.6%,both P0.01;AFP levels:(212.80±27.00) μg·L-1and(231.60±23.04)μg·L-1 vs(360.71±25.80)μg·L-1,both P0.01)].Serum AFP levels in group A,B and C were positively correlated with prognosis(r= 0.33,0.40 and 0.87,respectively;P0.05 or P0.01).Conclusion The levels of serum AFP can be used as indicators for determining the prognosis of severe hepatitis.