Resuscitation with Hypertonic Saline Solutions and Cell Function in Hemorrhagic Shock

Objective To research the effects of hypertonic saline on the treatment and cell function in hemorrhagic shock.Methods It was reproduced that an animal model of hemorrhaged(MAP=5.33kPa) for 30 minutes in rabbits.It was treated by saline solution,grouped as 5 groups in 0.9%、2.5%、5.0%、7.5%、10.0%NaCl.It was analyzed in MAP and Na~+、Cl~-、K~+、NAG、MDA in plasma and survival times in rabbits.Results The MAP of 7.5% NaCl groups was significantly greater than others,but the level of K~+、NAG、MDA was significantly lower than others,the survival times in 7.5% NaCl groups were the longest among the 5 groups.Conclusion These studies suggest that cell injury may be decreased in resuscitation with 7.5% NaCl in hemorrhagic shock.