Measurement of Periodontal Inflammation Index with Spectroscopy

Objective:To further evaluate the ability of optical spectroscopy in the different individual groups to determine simultaneously multiple inflammatory indices in periodontal tissues in vivo.Methods:Spectra were obtained,processed and evaluated from healthy(n=54),gingivitis(n=50) and periodontitis(n=26) sites using a portable optical,near infrared spectrometer.A modified Beer-Lambert unmixing model that incorporates a nonparametric scattering loss function was still used by our team of international collaboration to determine the relative contribution of each inflammatory component to the overall spectrum.Results:Optical spectroscopy was successfully to further regenerate complex inflammatory profiles of periodontal tissues.Tissue oxygenation at periodontitis sites was significantly decreased(P0.05) compared to sites with gingivitis and healthy controls.This was largely the result of an increase in deoxyhemoglobin in the periodontitis sites compared with healthy(P0.01) and gingivitis(p=0.05)sites.Tissue water content per se showed no significant difference between the sites,but a water index associated with tissue electrolyte levels and temperature differed significantly between periodontitis sites and both healthy and gingivitis sites(P0.03).Conclusion:Optical spectroscopy can simultaneously determine multiple inflammatory indices directly in the periodontal tissues in the individual group of a whole world.Visible,near-infrared spectroscopy has the potential to be developed into a simple,reagent-free,a noninvasive,chair side,site-specific,diagnostic and prognostic test for periodontitis.