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Effects of Exendin-4 on Expression of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Renal Tissue of Type 2 Diabetic Rats

Geng Yan

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Abstract

Objective To observe the effects of exendin-4 on the expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the renal tissue of type 2 diabetic rats. Methods The diabetic rats were divided into 4 groups: diabetes mellitus group(DM group), low dose of exendin-4 group(EL group), middle dose of exendin-4 group(EM group), high dose of exendin-4 group(EH group). After 6 weeks, the expression of MMP-9 and TIMP-1 in renal tissue was measured by immunohistochemistry. Results The expression of MMP-9 and TIMP-1 in DM group was higher than that in NC group(P0 .01), while the expression of MMP-9 and TIMP-1 in all doses of exendin-4 groups was lower than that in DM group(P0 .01).Conclusion Exendin-4 has some renoprotective effect on type 2 diabetic rats, partly through down-regulating the expression of MMP-9 and TIMP-1.

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Objective To observe the effects of exendin-4 on the expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the renal tissue of type 2 diabetic rats. Methods The diabetic rats were divided into 4 groups: diabetes mellitus group(DM group), low dose of exendin-4 group(EL group), middle dose of exendin-4 group(EM group), high dose of exendin-4 group(EH group). After 6 weeks, the expression of MMP-9 and TIMP-1 in renal tissue was measured by immunohistochemistry. Results The expression of MMP-9 and TIMP-1 in DM group was higher than that in NC group(P0 .01), while the expression of MMP-9 and TIMP-1 in all doses of exendin-4 groups was lower than that in DM group(P0 .01).Conclusion Exendin-4 has some renoprotective effect on type 2 diabetic rats, partly through down-regulating the expression of MMP-9 and TIMP-1.

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Available abstract

Objective To observe the effects of exendin-4 on the expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the renal tissue of type 2 diabetic rats. Methods The diabetic rats were divided into 4 groups: diabetes mellitus group(DM group), low dose of exendin-4 group(EL group), middle dose of exendin-4 group(EM group), high dose of exendin-4 group(EH group). After 6 weeks, the expression of MMP-9 and TIMP-1 in renal tissue was measured by immunohistochemistry. Results The expression of MMP-9 and TIMP-1 in DM group was higher than that in NC group(P0 .01), while the expression of MMP-9 and TIMP-1 in all doses of exendin-4 groups was lower than that in DM group(P0 .01).Conclusion Exendin-4 has some renoprotective effect on type 2 diabetic rats, partly through down-regulating the expression of MMP-9 and TIMP-1.

Key concepts: Medicine, Tissue inhibitor of metalloproteinase, Matrix metalloproteinase, Matrix metalloproteinase 9, Immunohistochemistry, Internal medicine, Endocrinology, Diabetes mellitus

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Effects of Exendin-4 on Expression of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Renal Tissue of Type 2 Diabetic Rats — Research Paper | ScholarLens