Concurrent TMZ Chemotherapy with Radiotherapy for High Grade Glioma

Objective To evaluate the results of postoperative concurrent Temozolomide(TMZ)chemotherapy with radiotherapy for high grade glioma(HGG).Methods Thirty-seven patients with HGG were treated from Apr.2004 to Oct.2007.Twenty-two patients(11 of grage Ⅲ and 11 grade Ⅳ) were treated by concurrent TMZ chemoradiotherapy with radiotherapy(A group),and fiveteen patients(7 of grage Ⅲ and 8 of grade Ⅳ) were treated by radiotherapy along(B group).A group received concurrent TMZ chemoradiotherapy(75 mg/m2·d) for 6 weeks.Sequential TMZ chemotherapy(150-200 mg/m2·d) after the radiotherapy was carried out for 2-4 weeks.Sereotactic conformal radiotherapy was deli-vered by 6 MV/10 MV-X,and patients received overall DT 60-75 Gy.Hyperfractionated radiotherapy of 1.8-3 Gy/day were delivered,5 day/week.Results One and two years survival rates in A and B groups were 64.8% and 53.3%;40% and 26.7%,respectively.There was a significance difference between the concurrent TMZ chemotherapy with radiotherapy group and radiotherapy along group(P=0.002).This results showed that concurrent TMZ chemotherapy with radiotherapy increased survival times.Conclusions Concurrent TMZ chemotherapy with radiotherapy is much better than the radiotherapy along for HGG.It is worthy of clinical application.