COMPARISON THE CLINICAL EFFECT OF LETROZOLE AND CLOMIPHENE CITRATE ON OVULATION INDUCTION FOR PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Objective To compare the clinical effect of 2. 5 mg letrozole,5 mg letrozole and 50 mg clomiphene citrate for ovulation induction in women with polycystic ovary syndrome( PCOS). Methods A total of 90 patients with PCOS were randomly divided into three groups: 2. 5 mg letrozole,5 mg letrozole and 50 mg clomiphene citrate( n = 30). Patients were randomized to receive 2. 5 mg letrozole or 5 mg letrozole or 50 mg CC daily for 5 days beginning on the 3th day of the menstrual cycle or hemorrahge inducing by withdraw of progesterone. Follicular development was monitored using transvaginal ultrasound from day 10 onwards. When at least one follicle with a mean diameter≥ 18 mm was observed using transvaginal ultrasound,100 00 U of human chorionic gonadotrophin were given subcutaneously to trigger ovulation. Results Not only the number of mature follicles but also the time of follicles matured did not differ among the three groups. But the endometrial thickness on the day of HCG administration and ovulation were significantly higher in the two letrozole groups than in the CC group. There were no statistically significant differences in the pregnancy rate. Mean serum LH( and E2and P) level in three groups was almost similar. Miscarriage rate and OHSS rate and LUFS rate had no significant difference. Conclusion Letrozole had no negative effects in the endometrial thickness. 2. 5 mg / d letrozole and 5 mg / d letrozole is associated with a higher ovulation rate than CC in PCOS patients and may have a role as a first- line treatment for anovulatory patients with PCOS.