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2014•Hecheng huaxueRequires access

Synthesis and Anti-tumor Activities of Novel Pyrazole Derivatives Containing 1,3,4-Oxadiazole

Jin Wang

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Abstract

Seven novel pyrazole derivatives( 7a ~ 7g) containing 1,3,4-oxadiazole were designed and synthesized from 4-methoxyacetophenone. The structures were characterized by1 H NMR,IR and ESI-MS. The in vitro anti-tumor activities of 7a ~ 7g were investigated by MTT method. The results showed that 5-[3-( 4-methoxyphenyl)-1-benzylpyrazole-5-yl]-2-[N-( 4-bromophenyl) acetamide-2-ylthio]-1,3,4-oxadiazole( 7g) exhibited good inhibition activities against Hep G2 with IC50of60. 06 μM.

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What this paper is about

Seven novel pyrazole derivatives( 7a ~ 7g) containing 1,3,4-oxadiazole were designed and synthesized from 4-methoxyacetophenone. The structures were characterized by1 H NMR,IR and ESI-MS. The in vitro anti-tumor activities of 7a ~ 7g were investigated by MTT method. The results showed that 5-[3-( 4-methoxyphenyl)-1-benzylpyrazole-5-yl]-2-[N-( 4-bromophenyl) acetamide-2-ylthio]-1,3,4-oxadiazole( 7g) exhibited good inhibition activities against Hep G2 with IC50of60. 06 μM.

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Available abstract

Seven novel pyrazole derivatives( 7a ~ 7g) containing 1,3,4-oxadiazole were designed and synthesized from 4-methoxyacetophenone. The structures were characterized by1 H NMR,IR and ESI-MS. The in vitro anti-tumor activities of 7a ~ 7g were investigated by MTT method. The results showed that 5-[3-( 4-methoxyphenyl)-1-benzylpyrazole-5-yl]-2-[N-( 4-bromophenyl) acetamide-2-ylthio]-1,3,4-oxadiazole( 7g) exhibited good inhibition activities against Hep G2 with IC50of60. 06 μM.

Key concepts: Pyrazole, Chemistry, Oxadiazole, Acetamide, In vitro, Proton NMR, MTT assay, Combinatorial chemistry

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