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2005•Acta Universitatis Medicinalis Secondae ShanghaiRequires access

Inhibitive Effect of All-trans Retinoic Acid on Proliferation of Breast Cancer MCF-7 Cells

DU Xue-liang

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Abstract

Objective To study the effect of all-trans retinoic acid (ATRA) on proliferation of breast cancer MCF-7 cells. Methods The proliferation of MCF-7 cells under ATRA of different doses and interfering periods was observed and compared by MTT. Results The OD value of the experiment group 3, 6, 9 d after inoculation was significantly variable compared to that of the control group. The inhibiting effect of ATRA on the proliferation of MCF-7 cells was most apparent at 6 d after inoculation. Conclusion ATRA has inhibiting effect on the proliferation of MCF-7 cells, and this effect is dose and time dependent.

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What this paper is about

Objective To study the effect of all-trans retinoic acid (ATRA) on proliferation of breast cancer MCF-7 cells. Methods The proliferation of MCF-7 cells under ATRA of different doses and interfering periods was observed and compared by MTT. Results The OD value of the experiment group 3, 6, 9 d after inoculation was significantly variable compared to that of the control group. The inhibiting effect of ATRA on the proliferation of MCF-7 cells was most apparent at 6 d after inoculation. Conclusion ATRA has inhibiting effect on the proliferation of MCF-7 cells, and this effect is dose and time dependent.

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Available abstract

Objective To study the effect of all-trans retinoic acid (ATRA) on proliferation of breast cancer MCF-7 cells. Methods The proliferation of MCF-7 cells under ATRA of different doses and interfering periods was observed and compared by MTT. Results The OD value of the experiment group 3, 6, 9 d after inoculation was significantly variable compared to that of the control group. The inhibiting effect of ATRA on the proliferation of MCF-7 cells was most apparent at 6 d after inoculation. Conclusion ATRA has inhibiting effect on the proliferation of MCF-7 cells, and this effect is dose and time dependent.

Key concepts: MCF-7, Retinoic acid, Cell growth, Breast cancer, Cancer cell, Cancer research, Chemistry, Cancer

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