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2011•Xiandai shengwu yixue jinzhanRequires access

The Effect of Codon Optimization on the Immunogenicity of DNA Vaccine

Hejuan Du, LU Zhong-hua, Yiping Xing

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Abstract

DNA vaccine attracts more and more scholars,attention as a new achievement in development of vaccine.Many scholars always have been dedicated to enhance protection and immunogenicity of the DNA vaccine.Some experiment finds that codon optimization of DNA vaccine could improve protein expression and induce significantly humoral and cellular immune responses in mam-mal host cells.

About this research paper

What this paper is about

DNA vaccine attracts more and more scholars,attention as a new achievement in development of vaccine.Many scholars always have been dedicated to enhance protection and immunogenicity of the DNA vaccine.Some experiment finds that codon optimization of DNA vaccine could improve protein expression and induce significantly humoral and cellular immune responses in mam-mal host cells.

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Key contribution

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Method / approach

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Main findings

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Available abstract

DNA vaccine attracts more and more scholars,attention as a new achievement in development of vaccine.Many scholars always have been dedicated to enhance protection and immunogenicity of the DNA vaccine.Some experiment finds that codon optimization of DNA vaccine could improve protein expression and induce significantly humoral and cellular immune responses in mam-mal host cells.

Key concepts: Immunogenicity, DNA vaccination, Codon usage bias, Immune system, DNA, Virology, Biology, Recombinant DNA

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