ScholarLens Back to search
1996•Unpublished venueRequires access

IMMUNOHISTOCHEMICAL STUDY OF PCNA IN HEPATOCELLULAR CARCIN0MA AND THEIR PERICARCINOMA TISSUES

Huang Jieion

Open publisher page 0 citations

Abstract

Thirty nine cases of hepatocellular carcinoma(HCC)with their pericarcinomous tissues(PT) were studied immunohistochemically by using monoclonal antibodies PC10 to proliferating cell nuclearantigen(PCNA).The results showed that the PCNA positive rate of HCCs was very significantly higherthan that of PT,The lower the differentiation of HCC,the higher the PCNA positive rate. Among variouslesions of PT,small cell liver cell dysplasia was the highest one in PCNA positivity, The ratio of PCNApositivity to mototic figures in HCCs was 21: 1,but in erythroblasts of fetal liver(controls),it was 11:1.The latter was more approximate to the theoretical value,We suggested that this was due to endoreduplica-tion fo DNA in HCC cells.So,PCNA might be of practical use on the evaluation of the proliferation ofHCC.

About this research paper

What this paper is about

Thirty nine cases of hepatocellular carcinoma(HCC)with their pericarcinomous tissues(PT) were studied immunohistochemically by using monoclonal antibodies PC10 to proliferating cell nuclearantigen(PCNA).The results showed that the PCNA positive rate of HCCs was very significantly higherthan that of PT,The lower the differentiation of HCC,the higher the PCNA positive rate. Among variouslesions of PT,small cell liver cell dysplasia was the highest one in PCNA positivity, The ratio of PCNApositivity to mototic figures in HCCs was 21: 1,but in erythroblasts of fetal liver(controls),it was 11:1.The latter was more approximate to the theoretical value,We suggested that this was due to endoreduplica-tion fo DNA in HCC cells.So,PCNA might be of practical use on the evaluation of the proliferation ofHCC.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Thirty nine cases of hepatocellular carcinoma(HCC)with their pericarcinomous tissues(PT) were studied immunohistochemically by using monoclonal antibodies PC10 to proliferating cell nuclearantigen(PCNA).The results showed that the PCNA positive rate of HCCs was very significantly higherthan that of PT,The lower the differentiation of HCC,the higher the PCNA positive rate. Among variouslesions of PT,small cell liver cell dysplasia was the highest one in PCNA positivity, The ratio of PCNApositivity to mototic figures in HCCs was 21: 1,but in erythroblasts of fetal liver(controls),it was 11:1.The latter was more approximate to the theoretical value,We suggested that this was due to endoreduplica-tion fo DNA in HCC cells.So,PCNA might be of practical use on the evaluation of the proliferation ofHCC.

Key concepts: Proliferating cell nuclear antigen, HCCS, Immunohistochemistry, Hepatocellular carcinoma, Pathology, Dysplasia, Monoclonal antibody, Cell growth

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
IMMUNOHISTOCHEMICAL STUDY OF PCNA IN HEPATOCELLULAR CARCIN0MA AND THEIR PERICARCINOMA TISSUES — Research Paper | ScholarLens