Relationship between plaque composition and remodeling in coronary lesions assessed by intravascular ultrasound in patients with stable angina pectoris

Objective:To explore the relationship between plaque composition and vascular remodeling in coronary lesions as assessed with intravascular ultrasound in patients with stable angina pectoris.Method:Lesions of culprit coronary artery in patients with stable angina pectoris(SAP) were studied using intravascular ultrasound(IVUS) before coronary intervention.All patients were divided into two groups based on the value of remodeling index(RI): group A had a remodeling index of 1.0(negative remodeling) and group B had a remodeling index of ≥1.0(positive remodeling).These patients' lesions were divided into two groups with lumen area narrowing ≥70% and 70%.Result:①Comparing by remodeling types: the plaque burden was significantly greater at proximal reference segment in group A than in group B.The lumen area and external elastic membrane(EEM) area was minor at lesions in group A than in group B.The plaque burden was significantly greater at lesions in group A than in group B.The incidence of hard plaque was higher in group A than in group B.The maximal arc of calcium and length in lesion was more in group A than in group B.②Comparing by lumen area narrowing: the frequency of negative remodeling was minor in lesion sites with a lumen area narrowing of 70% than that of ≥70%.There was higher incidence of high soft plaque in the former than in the latter.There was some characteristics in the former than in the latter:greater lumen area,but minor plaque area and plaque burden;greater RI;the minor maximal arc of calcium in lesions.Conclusion:IVUS assessment of coronary plaques with a wide range of lumen narrowings demonstrated that plaque calcium predominates in lesions with negative vascular remodeling and in lesions with more severe lumen narrowing.Negative vascular remodeling was more frequent in more severe stenoses.