The relationship of adiponectin, leptin and adiponectin-leptin ratio with components of metabolic syndrome in patients with type 2 diabetes

Objective To evaluate the associations of adiponectin, leptin, and their ratio (adiponectin/ leptin) with components of metabolic syndrome in patients with type 2 diabetes. Methods Two hundreds and sixty patients with newly diagnosed type 2 diabetes were investigated. The relationships of adiponectin, leptin and adiponectin/leptin(A/L) ratio with components of metabolic syndrome were studied. Results The odds ratio of A/L ratio affecting the occurrence of metabolic syndrome was 0.368 (95% CI, 0.171～0.791, P0.057). Overweight/obese patients had significantly lower levels of adiponectin and A/L ratio and higher leptin as compared with nonobese subjects. Insulin-sensitive patients had significantly higher levels of adiponectin and A/L ratio and lower leptin than those with IR after adjusting body mass index(BMI) and waist circumference. Conclusions For type 2 diabetes patients, adiponectin, leptin, A/L ratio are associated with obesity, insulin resistance, and the components of the metabolic syndrome.