Research Advancement about Pathogenesis of Crouzon Syndrome

Crouzon syndrome is an autosomal dominant inherited disease with craniosynostosis.Premature fusion of the skull bone sutures will result in narrow cavity of skull,shallow eye sockets,ophthalmoptosis,hooknose,maxillae dysplasia,relative prognathism and so on,which will then result in some complications including acute intracranial hypertension,loss of sight and so on.As for the majority of Crouzon syndrome,its gene is located on the gene domain of fibroblast growth factor receptor 2 in chromosome 10q25～q26.The regulatory factors that maybe take part in the genesis of this disease are fibroblast growth factor,basic fibroblast growth factor,tumor necrosis factor β,noggin and so on.Sporadic cases occupies a considerable proportion of Crouzon syndrome,of which the onset maybe related to older paternal age.