Analysis of clinical and histopathological characters of nasopharyngeal carcinoma patients with distant metastasis at preliminary diagnosis

Objective To investigate the factors related to distant metastasis of nasopharyngeal carcinoma through analyzing the clinical and histopathological characters of nasopharyngeal carcinoma patients with distant metastasis at preliminary diagnosis.Methods Several clinical and histopathological characters were analyzed for 42 patients with nasopharyngeal carcinoma with distant metastasis at preliminary diagnosis.These factors included sex,course of disease,symptoms seen in the primary complain,T stage,N stage,location of neck masses(unilateral or bilateral neck node metastasis) and histopathological types.Results There was no difference in the distribution of cases with the factors including course of disease,symptoms seen in the primary complain,T stage,N stage and histopathological types.〖XCP331.TIF,JZ〗 =7.714、5.339、 0.095、0.381、2.381 respectively,P=0.052、0.149、0.758、0.537、0.123 respectively.There was significant difference in the distribution of cases with the factors including sex and location of neck masses(unilateral or bilateral neck node metastasis).〖XCP331.TIF,JZ〗=6.095、5.518 respectively,P=0.014、0.023 respectively.Conclusion There was no relativity between the distant metastasis and the most clinical characters.There was the more risk of distant metastasis at preliminary diagnosis in the nasopharyngeal carcinoma patients who is male or bilateral neck node metastasis.Active synthetical therapy should be applicable for such cases.