Analysis on the levels of IL-6,IL-10 and IL-17 in serum of patients with chronic hepatitis B

Objective: To explore the level of cytokines and their function in serum of patients with hepatitis B. Methods:Blood samples from 70 CHB patients and 20 healthy controls were collected. The levels of IL-6,IL-10 and IL-17 were detected by ELISA. We also tested the liver function of patients. Results: Compared with the healthy controls,CHB patients were significantly higher in the level of IL-6,IL-10 and IL-17( P 0. 05); compared with HBeAg negative,HBeAg positive were significantly lower in the level of IL-6( P 0. 05),while the level of IL-17 were higher( P 0. 05),the level of IL-10 was almost similar. The level of 3 cytokines was similar between HBV-DNA≥105copies / ml and 105copies / ml. IL-6 level showed positive correlation on AST,TBIL and HBV-DNA. Conclusion: IL-6,IL-10 and IL-17 might be involved in the pathogenesis of CHB,which level's alteration has a closer relationship with the level of liver inflammation and HBV DNA.