Primary application of whole brain CT perfusion in patients with stenosis or occlusion of middle cerebral artery

Objective To explore the value of the whole brain CT perfusion(CTP)in patients with stenosis or occlusion of middle cerebral artery(MCA).Methods Conventional cerebral plain CT and volume Shuttle CTP(8 cm spatial coverage)were performed in 20 patients with unilateral MCA stenosis or occlusion.The parameter maps of cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT)and time to peak(TTP)were analyzed.Meanwhile dynamic 3D-CT angiography images were obtained.Results In 20 patients with unilateral stenosis or occlusion of MCA,no significant differences were found between the stenosed or occluded side and the contralateral side assessed in MTT and TTP.MTT and TTP of affected side significantly prolonged compared with contralateral side([7.05±1.47]s vs [4.96±1.00]s and [20.04±2.14]s vs [17.83±1.89]s,P0.01).No significant difference of CBV nor CBF was detected between the stenosed or occluded side and the contralateral side assessed in 20 patients.Conclusion Volume Shuttle CTP provides valuable information on hemodynamic damage and MCA abnormalities in patients with MCA stenosis or occlusion.