Effects of valsartan on levels of nitric oxide and inflammatory factors in patients with hypertension accompanied with impaired glucose tolerance

Objective:To observe effects of angiotensin Ⅱ receptor blocker——valsartan on plasma levels of nitric oxide(NO) and inflammatory factors in patients with essential hypertension(EH) accompanied with impaired glucose tolerance(IGT).Methods: A total of 36 patients with EH accompanied with IGT received valsartan(80 mg,1 time/d) oral.Another 36 healthy people were chosen as normal control group.Changes of levels of blood pressure,fasting blood glucose,2h postprandial blood glucose(2hPG),homeostasis model-insulin resistance index(HOMA-IR),plasma inflammatory factors and NO were measured before and after treatment.Results:Compared with before treatment,there were significant decrease in levels of blood pressure[(163.95±8.0)/(99.10±11.8)mmHg vs.(132.93±10.7)/(82.14±9.5)mmHg],2hPG [(9.10±1.10) mmol/L vs.(7.85±1.15) mmol/L]and HOMA-IR[(3.90±2.11) vs.(2.73±1.71)],P0.01 all in EH patients accompanied with IGT on eight weeks after treatment with valsartan.Compared with before treatment,the levels of plasma TNF-α and IL-6 significantly decreased,and the level of plasma NO significantly increased after treatment,P0.01 all.Conclusion:Valsartan can decrease levels of plasma inflammatory factors and increase level of nitric oxide,improve insulin resistance and vascular endothelial diastolic function and inhibit inflammatory reactions.