The Analysis of the change about Intestinal Mucosal Barrier in Severe Acute Pancreatitis

Objective To explore the mechanism of the changes about the intestinal mucosal barrier in severe acute pancreatitis(SAP) in order to improve the treatment strategy.Methods Thirty-six patients diagnosed with SAP and 30 volunteers as the control group were enrolled into this research.The levels of serum tumor necrosis factor alpha(TNF-α),nitricoxide(NO),diamineoxidase(DAO) and plasma endotoxin(ET) were measured.The ratio of lactulose to mannitol(L/M) in urine was detected by HPLC with pulsed electroc hemical detection.Results Compared with the control group,there were significantly increasing about the parameters of serum TNF-α,NO,DAO and ET in the patients with SAP(P 0.01),so was the ratio of lactulose to mannitol in urine(P 0.01).Conclusion The intestinal mucosal barrier in the patients with SAP is injured and gut permeability is increased.Serum endotoxin,TNF-αand NO may play important roles in the damage of gut barrier,and DAO can reflect the integrity of the intestinal mucosa.