Research on anti-cancer activities of soybean protein hydrolysates

Soy protein isolate was treated as raw material.The hydrolysates with anti-cancer activities were prepared by enzymolysis separately with neutral protease,papain,alkaline protease and pepsin.The hydrolysis degrees and cancer cell growth inhibitory values of hydrolysates were detected.The results showed that the anti-cancer activity of the papain hydrolysate was 27.36%,higher than those of other protease hydrolysates,remarkably.The followed ones were neutrase hydrolysate(21.20%) and Alcalase hydrolysate(18.01%).The pepsin hydrolysate had the lowest cancer cell growth inhibitory value(11.20%).On the optimum enzymolysis conditions,the hydrolysis degree order of the soybean protein was like this: alkalaseneutrasepapainpepsin.There was no linear relationships between cancer cell growth inhibitory values and the hydrolysis degrees.