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2008•Ningxia Medical JournalRequires access

Expression and clinical significance of chemokine receptor CCR7 in oral squamous cell carcinoma

Dong Yin

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Abstract

Objective To examine the expression of CCR7 protein in oral squamous cell carcinoma(OSCC).Methods The expression of CCR7 protein in 64 cases of OSCC was examined by immunohistochemical technique.ResultsCCR7 was positively expressed in OSCC,and the positive expression rate of CCR7 protein was 65.6%(42/64).CCR7 expression was significantly higher in the patients with lymph node metastasis than those without lymph node metastasis(P0.0001),and was also correlated with tumor histological type(P0.05),depth of tumor invasion(P0.05),and TNM stage(P0.001).The expression was not correlated with age at surgery,gender,tumor size.Conclusion CCR7 is highly expressed in OSCC,and its expression is associated with the diverse progression of OSCC,including histological type,TNM stage and lymph node metastasis.

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What this paper is about

Objective To examine the expression of CCR7 protein in oral squamous cell carcinoma(OSCC).Methods The expression of CCR7 protein in 64 cases of OSCC was examined by immunohistochemical technique.ResultsCCR7 was positively expressed in OSCC,and the positive expression rate of CCR7 protein was 65.6%(42/64).CCR7 expression was significantly higher in the patients with lymph node metastasis than those without lymph node metastasis(P0.0001),and was also correlated with tumor histological type(P0.05),depth of tumor invasion(P0.05),and TNM stage(P0.001).The expression was not correlated with age at surgery,gender,tumor size.Conclusion CCR7 is highly expressed in OSCC,and its expression is associated with the diverse progression of OSCC,including histological type,TNM stage and lymph node metastasis.

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Available abstract

Objective To examine the expression of CCR7 protein in oral squamous cell carcinoma(OSCC).Methods The expression of CCR7 protein in 64 cases of OSCC was examined by immunohistochemical technique.ResultsCCR7 was positively expressed in OSCC,and the positive expression rate of CCR7 protein was 65.6%(42/64).CCR7 expression was significantly higher in the patients with lymph node metastasis than those without lymph node metastasis(P0.0001),and was also correlated with tumor histological type(P0.05),depth of tumor invasion(P0.05),and TNM stage(P0.001).The expression was not correlated with age at surgery,gender,tumor size.Conclusion CCR7 is highly expressed in OSCC,and its expression is associated with the diverse progression of OSCC,including histological type,TNM stage and lymph node metastasis.

Key concepts: C-C chemokine receptor type 7, Medicine, Immunohistochemistry, Stage (stratigraphy), Basal cell, Chemokine receptor, Lymph node metastasis, Chemokine

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Expression and clinical significance of chemokine receptor CCR7 in oral squamous cell carcinoma — Research Paper | ScholarLens