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Reversal Effect of As_2O_3 on Multidrug Resistance K_(562/ADM) Cell Line

Chao Liu

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Abstract

Objective To illustrate mechanisms of arsenic trioxide (As 2O 3) in the treatment of K 562 / ADM cells. Methods We study the reversal effect of As 2O 3 on K 562 / ADM MDR cells in experiment model of rat. Results ① The resistance of K 562 / ADM cell line to ADM was 40 times than that of K 562 cell line, but the IC 50 value of both cell lines to As 2O 3 was similar (P0.05); ② low cytotoxic dose (2.0 μmol/L) of As 2O 3 in combination with ADM (4.0 μg/ml) increased the intracellular ADM concentration (P0.05) and declined IC 50 value of K 562 / ADM cell line to ADM by 2.5 times than the control. Conclusion As 2O 3 might be an effective anti tumor drug as well as an effective drug for reversal of MDR.

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What this paper is about

Objective To illustrate mechanisms of arsenic trioxide (As 2O 3) in the treatment of K 562 / ADM cells. Methods We study the reversal effect of As 2O 3 on K 562 / ADM MDR cells in experiment model of rat. Results ① The resistance of K 562 / ADM cell line to ADM was 40 times than that of K 562 cell line, but the IC 50 value of both cell lines to As 2O 3 was similar (P0.05); ② low cytotoxic dose (2.0 μmol/L) of As 2O 3 in combination with ADM (4.0 μg/ml) increased the intracellular ADM concentration (P0.05) and declined IC 50 value of K 562 / ADM cell line to ADM by 2.5 times than the control. Conclusion As 2O 3 might be an effective anti tumor drug as well as an effective drug for reversal of MDR.

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Available abstract

Objective To illustrate mechanisms of arsenic trioxide (As 2O 3) in the treatment of K 562 / ADM cells. Methods We study the reversal effect of As 2O 3 on K 562 / ADM MDR cells in experiment model of rat. Results ① The resistance of K 562 / ADM cell line to ADM was 40 times than that of K 562 cell line, but the IC 50 value of both cell lines to As 2O 3 was similar (P0.05); ② low cytotoxic dose (2.0 μmol/L) of As 2O 3 in combination with ADM (4.0 μg/ml) increased the intracellular ADM concentration (P0.05) and declined IC 50 value of K 562 / ADM cell line to ADM by 2.5 times than the control. Conclusion As 2O 3 might be an effective anti tumor drug as well as an effective drug for reversal of MDR.

Key concepts: Multiple drug resistance, Arsenic trioxide, Intracellular, Cell culture, Cytotoxic T cell, Chemistry, Drug resistance, Pharmacology

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