Progress About the Generation of Transgenic Animals with Lentiviral Vector

Lentiviruse is a kind of retroviridae. Some of their characters are different from restroviruses though they possess the basic structures and components. Lentiviral vectors have been used as vector of gene therapy. Recently, these vectors are applied to generation of transgenic animals. DNA produced by lentiviruses genomic restro-transcription can integrate into host cell DNA as that produced by other restroviruses. Lentiviral vectors can't proliferate in host cells or cause host cell death after viruses are rebuilt. Host cells transformed by lentiviral vectors can proliferate and transfer. A considerable advantage of lentiviral vector is the ability at infecting still cells and non-generation of chimera animals. The construct principle of lentiviral vectors, and some progress about the present methods of production and application of transgenic animals were introduced in detail.;