NH Shear
Abstract
General wisdom has it that terbinafine, a commonly used oral treatment for dermatophyte infections, has no effect on P450 cytochromes. This study examined terbinafine's effect on CYP2D6, an important cytochrome P450 that metabolizes more than 35 drugs. CYP2D6 activity was tested in nine subjects who received 250 mg …
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General wisdom has it that terbinafine, a commonly used oral treatment for dermatophyte infections, has no effect on P450 cytochromes. This study examined terbinafine's effect on CYP2D6, an important cytochrome P450 that metabolizes more than 35 drugs. CYP2D6 activity was tested in nine subjects who received 250 mg …
Key concepts: Terbinafine, CYP2D6, Medicine, Dermatophyte, Pharmacology, Drug, Cytochrome P450, Dermatology