Clinical characteristics of 118 cases of hyperthyroidism with hepatic dysfunction

Objective To study clinical characteristics of hyperthyroidism with hepatic dysfunction.Methods 224 diagnosed hyperthyroid patients were present or not,the clinical manifestation,liver function tests,serum thyroid hormones,co-exist diseases and clinical treatment were reexamined in these patients.Results The prevalence of hepatic dysfunction was seen in 118 cases(52.7%) with illness duration over 6 months in 85 cases(72.0%),asymptomatics was seen in 70 cases(59.3%).Increased ALP and ALT were the most familiar abnormal hepatic function parameters.In the patients with hepatic dysfunction,the serum ALT and AST levels were correlated to FT3 and FT4 levels.The prevalence of co-existed hyperthyroid heart disease,myopathy,periodical paralysis and infiltrated exopthalmos was significantly higher in patients with hepatic dysfunction than normal hepatic function(P0.05).Over half patients with hepatic dysfunction recovered from antihyperthyroidism combined with resting,nutrition support and protection of liver function.Those of no effects from above treatment mostly recovered from corticosteroids.Conclusion Hepatic dysfunction was common in hyperthyroidism with asymptomatics.There was correlation between the elevation of liver function and the thyroid hormone levels,coexist diseases.Corticosteroids has effect to some hyperthyroidism with severe hepatic dysfunction.