Value of prostate specific antigen adjusted for transition zone volume in diagnosis of prostate cancer

Objective To study the value of prostate specific antigen adjusted for transition zone volume (PSATZ) in discriminating prostate cancer with benign prostatic hyperplasia.Methods Thirty-six patients were divided into three groups,the first group was the benign prostatic hyperplasia with the normal prostate specific antigen (PSA) level; the second group was the benign prostatic hyperplasia with the PSA(10.0) ng/ml; the third group was the prostate cancer with (4.0) ng/mlPSA≤(10.0) ng/ml.The volume of prostate and transition zone was obtained by transrectal ultrasound.Then prostate specific antigen density(PASD) was calculated by dividing the total serum PSA level by total prostate volume,and the total PSA level was also divided by the transition zone volume to yield PSATZ.Results PSAD of the second group and third group was greater than that of the first group[((0.31)±(0.14))ng/ml~2,((0.28)±(0.19))ng/ml~2 vs ((0.11)±(0.08))ng/ml~2,P(0.05)],but there was no statistic difference between the second and the third group; PSATZ of the second and third group was greater than that of the first group [((0.37)±(0.13))ng/ml~2,((0.51)±(0.11))ng/ml~2 vs ((0.15)±(0.07))ng/ml~2,P(0.05)],and that of the third group was greater than that of the second group significantly.Conclusions PSATZ was more accurate than PSAD in distinguishing prostate cancer with low PSA from benign prostatic hyperplasia with high PSA.