Effects of losartan and perindopril on ventricular remodeling and left ventricular function after AMI in rats

OBJECTIVE To investigate the effects of losartan and perindopril on ventricular remodeling and left ventricular function after AMI in rats.METHODS Animal models of AMI were made in rats and randomly divided into 5 groups: sham-operated group (S), control (C),losartan treatment(L),perindopril treatment(P) , and combined treatment (LP).After 6 weeks,the heart length, periphery, left ventricular weight,heart rate,blood pressure,left ventricular systolic pressure (LVSP),left ventricular end-diastolic pressure (LVEDP) and± dp/dt were measured.RESULTS The SBP, SDP, MAP and LVSP were significantly decreased in all the treated groups( P 0.01 or P 0.05) .Compared with S group,LVEDP was significantly increased in C( P 0.001)and the treated groups( P 0.05) , ±dp/dt was significantly decreased ( P 0.01) . LVEDP in the treated groups was lower than that in C group (P 0.01) .±dp/dt in the treated groups was higher than that in C group ( P 0.01) . The heart length and periphery and left ventricle weight were significantly increased in C groups( P 0.05). CONCLUSION Losartan and Perindopril could improve the left ventricular remodeling and heart functions in AMI rats.