The Application of Dexmedetomidine in Extubation of General Anesthesia in Thyroid Surgery

Objective:To dissuss the efficiency of application of dexmedetomidine in extubation of general anesthesia in thyroid surgery.Methods:A total of 60 patients with the American Society of Anesthesiology(ASA) Ⅰ-Ⅱ underwent resection of the thyroid gland or resection of thyroid carcinoma were randomly divided into 2 groups.Dexmedetomidine group(Group A):calculated the amount of 2 μg/mL dexmedetomidine solution based on 0.5 μg/kg and infused intravenously by a electronic micro-pump before 10 mins of the end of the surgery;The control group(Group C): infusing the same amount of saline instead of dexmedetomidine.Observing and recording HR,SP,DP,SpO2 of the patient at the time of baseline(T1),before infusing of dexmedetomidine or saline(T2),completion of dexmedetomidine or saline infusion(T3),during extubation(T4),1 minute after extubation(T5),15 minute after extubation(T6).Recording awaken time and extubation time,extubation agitation scores,cough scores,Ramsay sedation scores after extubation and pain of visual analogue scale(VAS).Recording the adverse events(arrhythmia,PONV,laryngospasm.etc)occurred in patients before leaving the PACU.Results: The blood pressure and heart rate of dexmedetomidine group were lower than the control group at the time of completion of drug infusion;during extubation and 1 minute after extubation(P0.05).The agitation scores,cough scores and VAS of dexmedetomidine group were also lower comparing with the control group(P0.05).More transient bardycardia and hypotension occurred in dexmedetomidine group(P0.05).Conclusions: In patients underwent thyroid surgery,the infusing of dexmedetomidine before extubation can make patients a comfortable sedation and stable hemodynamic state with adequate pain relief,while no significant delaying of awaken and extubation time.