2005•Zhōnghuá yàoxué zázhìRequires access

Study on pharmacokinetics of nimodipine polymorphs in rabbits

Yuan Heng-jie

Abstract

OBJECTIVE To study pharmacokinetics and relative bioavailability of nimodipine polymorphs in rabbits.METHODS According to the crossover design, each rabbit was orally given nimodipine polymorph capsules. The plasma concentrations were determined by HPLC. Pharmacokinetic parameters were calculated. The analysis of variance and two-one sided t test were used as statistical analysis.RESULTS After a single oral dose, Cmax were 46.70 and 39.64 ng·mL-1, tmax were 2.8 and 3.0 h, AUC0→t were 351.5 and 341.0 ng·h·mL-1 for nimodipine Ⅰ and Ⅱ.respectively. The relative bioavailability of nimodipine polymorphⅡ was 97.0% compared with Ⅰ . CONCLUSION Nimodipine polymorphs were bioequivalent.

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Key concepts: Nimodipine, Bioequivalence, Bioavailability, Pharmacokinetics, Cmax, Crossover study, Pharmacology, Chemistry