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2010•Journal of Clinical HematologyRequires access

Study on relationship between polymorphism site rs2004640 of IRF5 and SLE patients

Yuan Jiang-shui

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Abstract

Objective:To investigate single nucleotide polymorphism of interferon regulation factor 5 (IRF5) rs2004640 and its relationship with systemic lupus erythematosus (SLE) susceptibility in a population from Shandong province.Method:The polymorphism (rs2004640G/T) was detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 92 cases of SLE and 88 healthy controls.The genotype and allele frequencies were calculated and analyzed.Result:①The genotype frequencies of GG,GT and TT of rs2004640 in SLE were 0.198,0.521 and 0.281 respectively,which had a significant difference compared with those of controls (χ2= 8.73,P0.05).②The allele frequencies of T and G of rs2004640 in SLE were 0.402 and 0.598 respectively,which had a significant difference compared with those of controls (χ2= 7.41,P0.01).Conclusion:The polymorphism of IRF5 rs2004640 might be associated with SLE in the Han population from Shandong province of China.

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Objective:To investigate single nucleotide polymorphism of interferon regulation factor 5 (IRF5) rs2004640 and its relationship with systemic lupus erythematosus (SLE) susceptibility in a population from Shandong province.Method:The polymorphism (rs2004640G/T) was detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 92 cases of SLE and 88 healthy controls.The genotype and allele frequencies were calculated and analyzed.Result:①The genotype frequencies of GG,GT and TT of rs2004640 in SLE were 0.198,0.521 and 0.281 respectively,which had a significant difference compared with those of controls (χ2= 8.73,P0.05).②The allele frequencies of T and G of rs2004640 in SLE were 0.402 and 0.598 respectively,which had a significant difference compared with those of controls (χ2= 7.41,P0.01).Conclusion:The polymorphism of IRF5 rs2004640 might be associated with SLE in the Han population from Shandong province of China.

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Available abstract

Objective:To investigate single nucleotide polymorphism of interferon regulation factor 5 (IRF5) rs2004640 and its relationship with systemic lupus erythematosus (SLE) susceptibility in a population from Shandong province.Method:The polymorphism (rs2004640G/T) was detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 92 cases of SLE and 88 healthy controls.The genotype and allele frequencies were calculated and analyzed.Result:①The genotype frequencies of GG,GT and TT of rs2004640 in SLE were 0.198,0.521 and 0.281 respectively,which had a significant difference compared with those of controls (χ2= 8.73,P0.05).②The allele frequencies of T and G of rs2004640 in SLE were 0.402 and 0.598 respectively,which had a significant difference compared with those of controls (χ2= 7.41,P0.01).Conclusion:The polymorphism of IRF5 rs2004640 might be associated with SLE in the Han population from Shandong province of China.

Key concepts: Genotype, IRF5, Allele, Single-nucleotide polymorphism, Allele frequency, Polymorphism (computer science), Significant difference, Immunology

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