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2006•Carcinogenesis,Teratogenesis and MutagenesisRequires access

Inhibition Effect of Betulin on Oesophageal Cancer EC109 Cell Line

Cai Weijia

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Abstract

BACKGROUNDAIM: Betulin is an important triterpene.We investigated the antitumor activity of betulin,extracted from the bark of silver birch(Betula platyphylla Suk). MATERIAL AND METHODS: Betulin was isolated from dry powder of the bark of silver birch(Betula platyphylla Suk)by using ethanol circumfluence,decompress concentration and methanol-chloroform recrystallization.The inhibition rate on EC109cell growth was detected by MTT(Methylthiazoletetrazolium)method,after the oesophageal cancer EC109cells have been treated for48h with different doses of betulin. RESULTS: With the increasing doses of betulin,the inhibition rate of EC109cell growth was increased,and their morphological characteristics were changed significamtly.The inhibition rate showed dose-dependent relation. CONCLUSION: Betulin had potent inhibiting effects on EC109cells growth in vitro.

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BACKGROUNDAIM: Betulin is an important triterpene.We investigated the antitumor activity of betulin,extracted from the bark of silver birch(Betula platyphylla Suk). MATERIAL AND METHODS: Betulin was isolated from dry powder of the bark of silver birch(Betula platyphylla Suk)by using ethanol circumfluence,decompress concentration and methanol-chloroform recrystallization.The inhibition rate on EC109cell growth was detected by MTT(Methylthiazoletetrazolium)method,after the oesophageal cancer EC109cells have been treated for48h with different doses of betulin. RESULTS: With the increasing doses of betulin,the inhibition rate of EC109cell growth was increased,and their morphological characteristics were changed significamtly.The inhibition rate showed dose-dependent relation. CONCLUSION: Betulin had potent inhibiting effects on EC109cells growth in vitro.

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Available abstract

BACKGROUNDAIM: Betulin is an important triterpene.We investigated the antitumor activity of betulin,extracted from the bark of silver birch(Betula platyphylla Suk). MATERIAL AND METHODS: Betulin was isolated from dry powder of the bark of silver birch(Betula platyphylla Suk)by using ethanol circumfluence,decompress concentration and methanol-chloroform recrystallization.The inhibition rate on EC109cell growth was detected by MTT(Methylthiazoletetrazolium)method,after the oesophageal cancer EC109cells have been treated for48h with different doses of betulin. RESULTS: With the increasing doses of betulin,the inhibition rate of EC109cell growth was increased,and their morphological characteristics were changed significamtly.The inhibition rate showed dose-dependent relation. CONCLUSION: Betulin had potent inhibiting effects on EC109cells growth in vitro.

Key concepts: Betulin, Bark (sound), Cancer cell lines, Betula platyphylla, Triterpene, Chemistry, Traditional medicine, Recrystallization (geology)

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