2003•Yixue yanjiusheng xuebaoRequires access

Inhibition effects of verapamil on serum-induced proliferation of rabbit retinal pigment epithelial cells in vitro

Jiang Cai

Abstract

Objectives:To investigate the effects of verapamil on serum induced proliferation of rabbit pigment epithelial(RPE) cells so as to search for simple and effective medicine on PVR. Methods:The rabbit RPE cells(passage 2 to 5) were cultured with various concentrations of verapamil in DMEM.The effects of verapamil on the cell cycle of RPE were analyzed with flow cytometry. Results:Verapamil significantly inhibited the serum induced proliferation of RPE cells, prevented RPE from G 1 phase transiting to S phase. Conclusions:Verapamil significantly inhibits RPE cell proliferation, and it may become a promising drug on PVR.

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Key concepts: Verapamil, Flow cytometry, In vitro, Pharmacology, Cell growth, Retinal, Pigment, Retinal pigment epithelium