Resveratrol Reduces Myocardial Ischemia-Reperfusion Injury in Rats Through JNK

Objective To investigate the protective effect of resveratrol on myocardial ischemia- reperfusion injury. Methods Thirty six rats were randomly divided into three groups:control group,ischemia- reperfusion injury(I /R) group and resveratrol group. These rat hearts subjected to 30 min ischemia and 40 min reperfusion. Heart rate( HR),left ventricular diastolic pressure(LVDP),left ventricular end- diastolic pressure(LVEDP) and the maximum change rate of intraventricular pressure( ± dp /dtmax) were recorded before ischemia and at 20 and 40 min of reperfusion. The coronary effulent were collected before ischemia and at 20 and 40 min of reperfusion to measure creatine kinase(CK) and lactate dehydrogenase(LDH) activity. The infarct size and Jun Nterminal kinase(JNK) activity were calculated at 40 min of reperfusion. Results Resveratrol enhanced LVEDP,LVDP and the maximum change rate of intraventricular pressure( ± dp /dtmax). The infarct size,CK and LDH activity were lower in Resveratrol group than that in ischemia and reperfusion group. And JNK activity was also lower in Resveratrol group. Conclusion Resveratrol has protective effect on isolated myocardial ischemia and reperfusion injury,and JNK signaling pathway may play an important role in the mechanism.