2006•Xiandai yufang yixueRequires access

A NEW KINDLING MODEL INDUCED BY CORIARIA LACTONE IN SD RATS AND THE EXPRESSION OF P-170

Huaisu Li

Abstract

Objective:To detect the expression of P-170 in astrocytes and capillary endothelial in brains of SD rats kindled by Coriaria Lactone.Methods:The rats was observed by identifying the seizure stages and the expression of P-170 in the brains of all rats was tested by immunohistochemistry method.Result:Compared with unkindled rats and placebo rats,the expression of the P-170 staining in the brain samples of kindled rats were significantly increased.No dose relation has been observed in the staining area of P-170 in astrocytes of the brain samples from kindled rats(P0.05).Conclusion Kindling SD rats induced by intramuscular injection of CL can be used as an animal models of intractable epilepsy.

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Available abstract

Key concepts: Kindling, Immunohistochemistry, Epilepsy, Kindling model, Staining, Rat model, Intramuscular injection, Endocrinology