Systematic review of the relationship between genetic polymorphism of p73 4G14C-4A14T and the susceptibility to lung cancer

OBJECTIVE:To evaluate relationship between polymorphism of p73 4G14C-4A14T and susceptibility to lung cancer by means of Meta-analysis.METHODS: Studies from 2000-2010 were retrieved through Cochrane Library,Medline,Elsevier,Ovid,Highwire Press,PubMed,web of science,BIOSIS Preview,Joural Citation Reports,FMJS,EMMC database without language limitation to collect relevant papers.Odds ratio of p73 4G14C-4A14T genotype distributions in the group of patients with lung cancer and the group of healthy control was calculated.The Meta-analysis was applied with RevMan 5 software for Heterogeneity test and pooled OR calculation.RESULTS: Four case-control studies with 2 924 cases and 3 136 controls were analyzed by random effect model meta-analysis method.The pooled OR of p73 4G14C-4A14T genotype GC/GC vs GC/AT+AT/AT was 0.92(95%CI:0.69-1.22),and z statistics were 0.60.CONCLUSIONS: There is enough evidence currently to prove that there is no relationship between p73 4G14C-4A14T genetic polymorphism and susceptibility to lung cancer.It is demonstrated that the genetic polymorphism of p734G14C-4A14T is not the important risk factor for susceptibility to human lung cancer.