2009•Unpublished venueRequires access
Effect of dexamethasone on airway inflammation and the expression of signal transducers and activators of transcription 6 in asthmatic mice
Xiaohua Peng, Yang Yuan
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Abstract
Objective To investigate the effects of dexamethasone (DXM) on the airway inflammation and the expression of signal transducers and activators of transcription 6(STAT6) in asthmatic mice.Method The protein expressions of STAT6 in DXM group were detected by immunohistochemistry techniques.Results The total cell numbers in BALF,the absolute numbers of EOS in asthma group were all significantly higher than those in the control group(P<0.01);the total cell numbers in BALF,the absolute numbers of EOS in DXM group were all significantly lower than those in asthma group(P<0.01),DXM attenuated the airway inflammation of asthmatic mice.The expressions of STAT6 were mainly on the bronchial epithelium.STAT6 protein levels increased in lung tissues in asthma group.DXM significantly reduced the levels of STAT6 protein.There was a significant positive correlation between the absolute numbers of EOS in BALF and the content of STAT6 in the epithelial cells.Conclusion DXM can ameliorate the progression of airway inflammation following prolonged allergen challenge via regulation of STAT6/IL-4 signal pathway.