2005•Zhongguo shenjing jingshen jibing zazhiRequires access
The effect of artificial cold on incidence of stroke in rats with different blood pressure level
Huang Ru-xu
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Abstract
Objective To investigate the effect of artificial cold on incidence of stroke in rats with different blood pressure level. Methods 360 male Sprague-Dawley rats were used throughout the study. 180 rats were treated with artificial cold, 180 rats treated without cold. Each group was divided into 4 blood pressure level: normal blood pressure, 160～199 mmHg, 200～219 mmHg and ≥220 mmHg. The incidence of stroke was analyzed. Results There were significant differences in incidence of stroke between rats treated with and without cold, as between rats with blood pressure more and less than 220 mmHg. Incidence of stroke was higher in rats with serious cerebrovascular pathological changes. Logistic regression showed that hypertension was the unique independent risk factor for stroke. Conclusions High blood pressure and cold were associated with higher incidence of stroke. High blood pressure is an independent risk factor for stroke, and cold is an important facilitating factor. The cerebrovascular pathological changes are more obvious in stroke rats.