2011•Chinese Journal of Clinical Rational Drug UseRequires access

Study on the relationship between polymorphisms of nucleotide excision repair enzyme gene and sensitivity to chemotherapy in advanced gastric cancer

Jianwei Lu

Abstract

Objective To explore the relationship between polymorphisms of ERCC1 118 and XPD 751 and the response to fluoropymidine(5-Fu)/platin-based chemotherapy in advanced gastric cancer.Methods 91 cases were treated with 5-Fu/platin-based chemotherapy,and the genotypes of ERCC1 118 and XPD 751 were detected before the therapy.The relationship between the chemotherapy effect and genetic polymorphisms of ERCC1 118 and XPD 751 were observed.Results The chemotherapy efficiency rate of this group was 37.4%.The efficiency rates were of no significant difference among different genotypes of ERCC1 118(P0.05).The chemotherapy efficiency rate of XPD 751 Lys/Gln genotype was 11.1%,which was respectively lower than 38.0% and 100.0% of the Lys/Lys and Gln/Gln genotype,and the differences were statistically significant(P0.01).Conclusion Nucleotide excision repair enzyme XPD 751 polymorphism has something to do with the sensitivity to 5-Fu/platin based chemotherapy in advanced gastric cancer.

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Key concepts: ERCC1, Chemotherapy, Medicine, Genotype, Nucleotide excision repair, Single-nucleotide polymorphism, Internal medicine, Oncology