Retrospective analysis the relevance of serum HBsAg and HBV DNA levels in patients with chronic hepatitis B

Objective To analysis the relevance of the serum HBsAg and HBV DNA levels in patients with chronic hepatitis B(CHB),and to detect the HBsAg critical point levels used to determine the best high HBV DNA.Methods 239 cases CHB patients in Liuzhou Traditional Chinese Medicine Hospital from July2013 to May 2014 were collected.The levels of HBV DNA,HBsAg,HBeAg and ALT were detected.The results were analyzed statistically.Results The levels of HBsAg and HBV DNA in HBeAg positive group were all higher than that of HBeAg negative group,and the differences all had statistical significance(Pall 0.05).The levels of HBsAg and HBV DNA were positive correlated in all the CHB patients(r= 0.603,P 0.01).The levels of HBsAg and HBV DNA were positive correlated in HBeAg positive group(r= 0.555,P= 0.000),but there was no correlation in HBeAg negative group(r= 0.076,P- 0.426).The levels of HBsAg and HBV DNA were all positive correlated in before antiviral therapy group and after antiviral therapy group(r= 0.622,r=0.603,Pall= 0.000).The levels of HBsAg and HBV DNA were all positive correlated in high ALT group and low ALT group(r= 0.586.r= 0.578,Pall= 0.000).The levels of HBsAg and HBV DNA were positive correlated in high HBV DNA( 2000 copies/L) group(r= 0.637,P= 0.000),but there was no correlation in low HBV DNA( 2000 copies/L) group(r= 0.226,P= 0.057).HBsAg levels used to determine the best high HBV DNA critical point was 5.03 × 10~3 IU/mL,and the area under receiver operating characteristic curve was 0.727.Conclusion There are positive correlation between serum HBsAg and HBV DNA levels in CHB patients.HBsAg levels can be used for speculated the high levels of serum HBV DNA.