Clinical Observation of Aprepitant Combined with Tropisetron in the Prevention of Vomiting Induced by Cisplatin Chemotherapy

OBJECTIVE:To observe clinical efficacy and ADR of aprepitant combined with tropisetron in the prevention of vomiting induced by cisplatin chemotherapy. METHODS:Randomized self-cross controlled method was applied. All 60 patients who received two courses of cisplatin based chemotherapy were randomized into group AB and BA. Group AB received aprepitant combined with tropisetron in the first cycle while tropisetron alone in the second cycle. Group BA was given tropisetron alone in the first cycle while aprepitant combined with tropisetron in the second cycle. RESULTS:Among 59 patients who achieved the assessment of clinical response,the complete response rates of acute vomiting by aprepitant combined with tropisetron vs. tropisetron were 74.6% vs. 57.6%;the control rate were 91.5% vs. 81.4%,respectively(Z=-2.017,P=0.044);the complete response rate of delayed vomiting was 69.5% vs. 42.4%,and the control rates were 86.4% vs. 71.2%(Z=-3.112,P=0.002). The most common ADR in both regimens were hiccups,constipation,headache,dizziness,mouth dry,etc. There was no statistical significance in the incidence of ADR(P0.05). CONCLUSIONS:The aprepitant combined with tropisetron regimen is effective for acute and delayed vomiting induced by cisplatin chemotherapy,with tolerable toxcity profile.