CORRELATION BETWEEN THE IRREGULAR ANTIBODIES IN RH BLOOD TYPE SYSTEM AND HEMOLYTIC DISEASE OF THE NEWBORN(HDN)

[Objective]To study the distribution of the irregular antibodies of pregnant women and analyze the correlation between irregular antibodies in Rh blood type system and HDN.[Methods]The serum irregular antibodies of 785 pregnant women were detected. Among them,the Rh blood type detection was done on the husbands and infants whose wives and mothers were with the positive irregular antibodies,and specific antibodies,immunoglobulin types and titer were also examined on 6 pregnant women and their children. When they delivered,the cord blood of the pregnant women or newborn infants' serum were collected to detect HDN with direct antiglobulin test,serum free antibody test,absorption and elution test.[Results]Among 785 pregnant women,7 pregnant women had irregular antibodies by screening,and the positive rate was 0.89%. There were 6 cases and 1 case in Rh system and Kidd system,respectively. And 85.7 % antibodies belonged to Rh system,in which RBC of 5 newborns were actived by irregular antibodies from their mothers and were caused HDN. These irregular antibodies were anti-cE,anti-E,anti-c,anti-D and anti-Ce,and anti-E(including anti-cE)was common.[Conclusion]Irregular antibodies in Rh blood type system may lead to HDN easily,so it is very important to detect irregular antibodies of pregnant women to diagnose and prevent non-ABO HDN earlier.