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Research Advances in Tetrodotoxin and Its Fermentation

Chen Xuan-xiong

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Abstract

Tetrodotoxin(TTX) is a highly toxic amino hydrogenated quinazoline compound in puffer fish.TTX is one of the most lethal biological toxins.It is also a powerful anesthetic and detoxification agent.Therefore,further studies on preparation technology and high-yield strategies of TTX for extending its medicinal values are being conducted according to the understanding of its generation pathways and TTX-producing strains.In this paper,basic characteristics of TTX including the origin,physical and chemical properties,biological activity are reviewed.In addition,current hot research direction and corresponding issues such as TTX-producing strain and its fermentation are also comprehensively analyzed.

About this research paper

What this paper is about

Tetrodotoxin(TTX) is a highly toxic amino hydrogenated quinazoline compound in puffer fish.TTX is one of the most lethal biological toxins.It is also a powerful anesthetic and detoxification agent.Therefore,further studies on preparation technology and high-yield strategies of TTX for extending its medicinal values are being conducted according to the understanding of its generation pathways and TTX-producing strains.In this paper,basic characteristics of TTX including the origin,physical and chemical properties,biological activity are reviewed.In addition,current hot research direction and corresponding issues such as TTX-producing strain and its fermentation are also comprehensively analyzed.

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Available abstract

Tetrodotoxin(TTX) is a highly toxic amino hydrogenated quinazoline compound in puffer fish.TTX is one of the most lethal biological toxins.It is also a powerful anesthetic and detoxification agent.Therefore,further studies on preparation technology and high-yield strategies of TTX for extending its medicinal values are being conducted according to the understanding of its generation pathways and TTX-producing strains.In this paper,basic characteristics of TTX including the origin,physical and chemical properties,biological activity are reviewed.In addition,current hot research direction and corresponding issues such as TTX-producing strain and its fermentation are also comprehensively analyzed.

Key concepts: Tetrodotoxin, Fermentation, Detoxification (alternative medicine), Chemistry, Yield (engineering), Strain (injury), Biotechnology, Biology

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