Protective effects of bamboo leaves extracts on experimental myocardial infarct in dogs

Objective To study the protective effects of bamboo leaves extract(BLE)on experimental dog myocardial infarction.Methods Models of acute myocardial infarction were prepared by ligating the left anterior descending coronary artery of a dog.The anti-myocardial ischemia action was assessed by determing the changes in myocardial infarct size (MIS),(-ST and N-ST) and serokinases.Its probable mechanism of action was proposed in view of the resultant myocardial metabolic changes and free radical injury.Results The activities of serum creatine phosphokinase and lactic dehydrogenase were also decreased,and the activities of superoxide dismutase were enhanced.At the same time,BLE (5,10, 20 mg·kg~ -1) also decreased the MIS in dogs induced by coronary occlusion.Myocardial oxygen consumption was also lowered.Conclusion These findings suggest that BLE is beneficial for myocardial ischemia,probably by inhibiting oxygen free radical formation and enhancing endogenous antioxidase activity,reducing myocardial oxygen consumption and reducing the MIS in dogs.