Absorbing,elimination and bioavailability of ciprofloxacin lactate in Cyprinus carpio

The pharmacokinetics of ciprofloxacin lactate following intravenous (IV), oral administration of ciprofloxacin lactate solution and oral administration of ciprofloxacin lactate mixed diet at 10.0mg·kg-1 body weight have investigated in healthy carps. The plasma drug concentrations were determined by HPLC. The data were analyzed by MCPKP software. The bioavailability of oral administration of ciprofloxacin lactate solution and oral administration of ciprofloxacin lactate mixed diet is 10.25% and 6.22% respectively. The data were described by the three compartment open model after IV. Following IV administration, ciprofloxacin lactate was well-distributed and slowly eliminated .The main pharmacokinetic parameters were as follows: t1/2α=0.16h、t1/2π=0.86h、t1/2β=16.47h、V1 =0.10 L·kg-1、Vb=3.03 L·kg-1、Clb = 0.12 L·kg-1·h-1. The data were described by the two compartments open model with a lagtime after oral administration of ciprofloxacin lactate solution and oral administration of ciprofloxacin lactate mixed diet. The absorbing rate of ciprofloxacin lactate is higher after oral administration of ciprofloxacin lactate solution than oral administration of ciprofloxacin lactate mixed diet. The main pharmacokinetic parameters were after oral administration of ciprofloxacin lactate solution as follows; t1/2α=0.31h、 t1/2β=6.47h、Cmax=2.14μg· mL-1、Tmax=0.44h. The main pharmacokinetic parameters were after oral administration of ciprofloxacin lactate mixed diet as follows: t1/2α=0.53h、t1/2β=14.47h、Cmax=0.70μg·mL-1、Tmax=1.10h . As result of the low bioavailability, it is unsuitable to use ciprofloxacin to cure the bacterial infection of carp.