2011•Linchuang gandanbing zazhiRequires access
The efficacy of entecavir in the treatment of patients with hepatitis B
Jun Ye
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Abstract
Objective To evaluate the efficacy of entecavir in the treatment of patients with chronic hepatitis B.Methods 43 patients with HBeAg positive and 18 with HBeAg negative were treated with entecavir for 48 weeks.Results The HBV DNA negative rates in the HBeAg negative group were 83.3% and 94.4%,higher than 34.9% and 65.1% in the HBeAg positive group at week 24 and week 48(P=0.001 and 0.018,respectively),while the ALT normalization rates between the two groups had no significant difference(P=0.713 and 0.138);in 34 patients with serum HBV DNA1×107 copies/ml and 27 with serum HBV DNA1×107copies/ml,the HBV DNA negative rates at week 24 were 32% and 70%,respectively(P=0.03),while those at week 48 were 68% and 81%,respectively(P=0.22).Conclusions Entecavir has significant anti-viral activity in the treatment of patients with CHB.