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Extraction of tetracycline using alcohol and ionic liquid binary aqueous two phase system

Zhang Zhong-ji

Abstract

Using ionic liquid 1-butyl-3-methylimi-dazolium tetrafluoroborate([Bmim]BF4) with NaH2PO4 binary aqueous two phase system for the extraction of tetracycline was developed. The influence factors on partition behaviors of tetracycline were studied,including concentration of NaH2PO4,pH value,concentration of ionic liquid and tetracycline. The results showed that when using pH value of 4. 0 ~ 5. 0,NaH2PO4 concentration of 36% and tetracycline concentration between 65 ~ 95 mg/L,the extraction rate and distribution coefficient of tetracycline will be up to 91. 98% ~ 94. 98% and 82. 135 ~ 130. 315,respectively.

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Available abstract

Key concepts: Tetracycline, Partition coefficient, Chemistry, Extraction (chemistry), Ionic liquid, Chromatography, Aqueous solution, Ionic strength