Intra-arterial thrombolysis in 28 patients with acute internal carotid circulation infarction

Objective To evaluate the safety and efficacy of intra-arterial thrombolysis in patients with acute internal carotid circulation infarction.Methods Twenty-eight patients with acute internal carotid circulation infarction were treated with intra-arterial urokinase.Intracerebral hemorrhage(ICH)was investigated immediately and 24 h after the treatment by CT scanning.Barthel Index(BI)was used to evaluate the recovery of neurological functions 90 d after the treatment.Results Of the 28 patients,18 achieved complete recanalization,6 partial recanalization and 4 didn't get any recanalization.ICH was observed in 6 patients.4 patients died.90 d later,14 patients had a good outcome,8 a median outcome and 6 a poor outcome or died.The living status of patients with recanalization was significantly better than that of ones with partial recanalization and non-recanalization.Conclusion The rates of ICH and death following intra-arterial thrombolysis are high.The therapeutic outcome of recanalization is good.